{
  "ok": true,
  "route": "/api/rrms1740",
  "bridge_route": "/api/rrms-1740-bridge",
  "bridge_face": "/rrms-1740-bridge/",
  "jetbase_trials_route": "https://jetbase-production.up.railway.app/api/clinical/trials",
  "dghealth_contract_route": "/api/dghealth-validation-contract",
  "law": "Same house. Distinct run ID. No fusion. No second harness.",
  "canonical": "dcgp-ai/circuits/rrms_1740q_bridge.py + dcgp-ai/circuits/rrms_1740q_ingestion.py",
  "face": "/rrms-1740-susan/",
  "alias": "/rrms-1740/",
  "cohort": "FEN1",
  "available_cohorts": [
    "RRMS",
    "REMY_VEP",
    "SLROP",
    "FEN1",
    "PARKINSON",
    "ONC",
    "GOAU_199",
    "PHARMA",
    "ALZR1",
    "CD"
  ],
  "spec": {
    "run_id": "FEN1-NSCLC-001",
    "trial_id": "FEN1-NSCLC-001",
    "disease": "Case II FEN1 NSCLC replication-fork governance watch",
    "matrix": "48x11",
    "bridge": "Case II FEN1 Watch",
    "dataset": "zenodo:4936837"
  },
  "sequence": [
    "replay",
    "freeze",
    "blind",
    "fire",
    "reveal",
    "score"
  ],
  "prediction_status": "PREDICTIONS_SEALED",
  "trial_record": {
    "trial_id": "FEN1-NSCLC-001",
    "domain": "FEN1 — Case II Molecular Governance at the DNA Repair Fork (NSCLC)",
    "category": "FEN1",
    "title": "Case II FEN1 Flap Endonuclease-1 Replication-Fork Co-Option & SLFN11 Gate Watch Trial",
    "register_id": "DISCOVERY",
    "dghealth_contract_id": "DGHEALTH-PROS-2026-FEN1-001",
    "target_metric": "sNfL_pg_ml",
    "rows": 48,
    "endpoints": 11,
    "prospective_eligible": true,
    "status": "PREDICTIONS_SEALED",
    "source_sha256": "5818242d468f92480337b6dbb9529a96a25c460a82b4179801ef9e8b7de65a80",
    "baseline_sha256": "ec02ce4815dfb016111ecf93b443d8243e6646615824774c19e17027e08d781b",
    "prediction_sha256": "3f8e1f3933bd156bba3567354a605f6040b7ddfde803577dadfcdd8cb5585339",
    "comparators": [
      "Case II FEN1 Watch Seat",
      "SLFN11 Gate Restorer (Q_L Proxy)",
      "PARPi Olaparib"
    ],
    "aura116_routes": [
      "/api/fen1",
      "/api/pharma-collider",
      "/api/rrms-1740-bridge"
    ],
    "dghealth_routes": [
      "/docgrokhealth/",
      "/api/pharma-collider"
    ],
    "validation_summary": {
      "validation_completed": true,
      "case": "II",
      "seat": "WATCH",
      "echo": false,
      "law": "FEN1 is co-option. Not the Echo channel. MAGI does not deplete FEN1."
    },
    "dghealth_contract": {
      "schema_identity": "dghealth.validation.contract.v1",
      "metadata": {
        "contract_id": "DGHEALTH-PROS-2026-FEN1-001",
        "trial_id": "FEN1-NSCLC-001",
        "created_at": "2026-10-24T06:15:00Z",
        "author": "Joshua L. Lopez / DCGP.AI",
        "target_domain": "FEN1 — Case II Molecular Governance at the DNA Repair Fork (NSCLC)",
        "governing_authority": "DG Health / AURA-GUARD / DELTA-031"
      },
      "translational_state_contract": {
        "input_state_vector_xt": {
          "clinical_vector": [
            "SDMT_score",
            "10MWT_seconds",
            "EDSS_baseline"
          ],
          "biomarker_vector": [
            "sNfL_pg_ml"
          ],
          "imaging_vector": [
            "P100_latency_ms",
            "P100_amp_uV",
            "pRNFL_um",
            "GCIPL_um",
            "MTR_ratio",
            "MWF_fraction",
            "Caspr_density"
          ],
          "material_vector": [
            "GO_scaffold",
            "Au197_witness",
            "NaYF4_Yb_Tm_ALZR1"
          ],
          "tissue_vector": [
            "echo_reinstatement_index"
          ]
        },
        "governed_representation_Q": {
          "metric_tensor_g": "sym(g0) + alpha*w(r)*grad(rho_Au)grad(rho_Au)^T + epsilon*I",
          "minimum_eigenvalue_lambda_min": 0.33628,
          "floating_equilibrium_S_star": "S_star_governed_manifold",
          "composite_viability_sigma": "min(sigma_axis, sigma_geom)"
        },
        "frozen_decoder_D": "inverse_transform_to_biological_units_v1"
      },
      "qapo_and_runtime_constraints": {
        "qhp_identity": "fen1_nsclc_001",
        "svg_structural_memory_hash": "5818242d468f92480337b6dbb9529a96a25c460a82b4179801ef9e8b7de65a80",
        "circuit_qasm_hash": "ec02ce4815dfb016111ecf93b443d8243e6646615824774c19e17027e08d781b",
        "qapo_constraints_Pi_K": [
          "sigma(z) >= 0",
          "sigma(z) >= sigma(x_t) - delta_sigma",
          "grad(sigma(z)) dot (z - x_t) >= 0",
          "Q_L <= 1.611000"
        ],
        "execution_service": "jetbase-delta31-rex-p3q",
        "random_seed_lock": 1744
      },
      "sealed_prediction_block": {
        "target_timepoints": [
          "t_0_baseline",
          "t_1_post"
        ],
        "target_metric": "sNfL_pg_ml",
        "cryptographic_prediction_seal": "3f8e1f3933bd156bba3567354a605f6040b7ddfde803577dadfcdd8cb5585339"
      },
      "evidence_ladder_status": {
        "L0_structural": "VERIFIED",
        "L1_computational": "VERIFIED",
        "L2_quantum_hardware": "NOT_EXECUTED",
        "L3_retrospective_biological": "ACTIVE",
        "L4_prospective_experimental": "ACTIVE_LOCKED_SEAL",
        "L5_prospective_human": "NOT_APPLICABLE",
        "L6_clinical": "NOT_ESTABLISHED"
      }
    }
  },
  "rrms_1740_bridge_001": null,
  "all_dghealth_trials_count": 10,
  "clinical_claim": false,
  "research_only": true,
  "braket": false,
  "ts": "2026-10-27T21:49:22.890Z"
}